The tumour suppressor C/EBPd inhibits FBXW7 expression and promotes mammary tumour metastasis
نویسندگان
چکیده
Kuppusamy Balamurugan, Ju-Ming Wang, Hsin-Hwa Tsai, Shikha Sharan, Miriam Anver, Robert Leighty and Esta Sterneck* Laboratory of Cell and Developmental Signalling, CCR, National Cancer Institute, Frederick, MD, USA, Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan, Pathology/Histotechnology Laboratory, SAIC-Frederick, National Cancer Institute, Frederick, MD, USA and Data Management Services Inc., National Cancer Institute, Frederick, MD, USA
منابع مشابه
The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis.
Inflammation and hypoxia are known to promote the metastatic progression of tumours. The CCAAT/enhancer-binding protein-δ (C/EBPδ, CEBPD) is an inflammatory response gene and candidate tumour suppressor, but its physiological role in tumourigenesis in vivo is unknown. Here, we demonstrate a tumour suppressor function of C/EBPδ using transgenic mice overexpressing the Neu/Her2/ERBB2 proto-oncoge...
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Hypoxia contributes to major aspects of cancer biology such as angiogenesis, glucose/energy metabolism, invasion and metastasis. The activation of hypoxiainducible factor 1a (HIF-1a) is a key step that promotes the transcriptional activation of target genes fundamental for these processes. In this issue of EMBO Journal, Balamurugan et al provide new insights on how hypoxia control integrates wi...
متن کاملThe Tumour Suppressor C/EBP delta Inhibits FBXW7 Expression and Promotes Mammary Tumour Metastasis
Thank you very much for submitting your research manuscript for consideration to The EMBO Journal editorial office. Three scientists provided their comments and assessment of the study that you will find enclosed below. All three referees appreciate the findings of C/EBPdelta as tumor suppressor that does however also contribute to tumor metastasis presumably by targeting FBXW7/mTOR signaling. ...
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